They are only worthwhile if unopened and retaining their contents. So yes, digitise them and throw them away.

[Says someone with a bottom shelf of empty (but rather sturdy) RPG boxes without anything actually in them). Then again, I'm slowly digitising many of the old RPG stuff I've got because having them on computer is easier than looking for them. Especially since I still have to try to unjam my filing cabinet (which unfortunately has a rear locking bar so it's a non-trivial exercise). Then again, even opened, many of these boxes (with contents reunited) are now worth lots of money. Bur that implies I'd be willing to sell, so that consideration doesn't matter (my heirs might, but I doubt they would realise the value and would just ditch them as rubbish).]

The only problem is that virtual objects tend to get lost more easily in the virtual clutter, whereas physical objects can remind you of good times every time you clean up. Not that I expect these to be a source of good collateral memories, but if they are, it might be a good idea to put those that are aside.